Grupo de Investigación y Desarrollo en Ciencias Aplicadas a los Recursos Biológicos

We've never really understood it.

A shocking revelation.

Beyond the point of no return.

A test to show the disease approaching?

Very concerning.

Short-term (with a lead time of about one week) earthquake (EQ) prediction is one of the most challenging subjects in geoscience and applied science; however, it is highly required by society because it is of essential importance in mitigating the human and economic losses associated with EQs. Electromagnetic precursors have recently been agreed to be […]

This study proposes a three-dimensional upper bound solution for estimating the soil thrust of tracked vehicles on saturated clay slopes. The present study considered block, triangular wedge, and trapezoidal wedge failure modes to formulate an upper bound solution for each. The analytical solution for soil thrust was determined as the minimum upper bound solution among […]

Gold nanoparticles (AuNPs) radiolabeled with therapeutic and diagnostic radioisotopes have been broadly studied as a promising platform for early diagnosis and treatment of many diseases including cancer. Our main goal for this study was the comparison of the biodistribution profiles of four different concentrations of gold nanoconjugates radiolabeled with Technetium-99m (99mTc). More specifically, AuNPs with […]

This study presents the effects of piston bowl size on the characteristics of a four-stroke single-cylinder diesel engine, which is considered in relation to changes in factors such as fuel injection pressure and turbocharger pressure. The study was carried out by 3D modeling using AVL Fire with an omega combustion chamber size and dimensions determined […]

Today, Permanent Magnet Synchronous Motors (PMSMs) are a dominant choice in industry applications. During operation, different possible faults in the system can occur, so early and automated fault detection and severity estimation are required to ensure smooth operation and optimal maintenance planning. In this direction, outlier detection methods are employed in this paper. The motor’s […]

Chebulae Fructus (CF) is known as one of the richest sources of hydrolyzable tannins (HTs). In this study, ultra-performance liquid chromatography coupled with a photodiode array detector method was established for simultaneous determination of the 12 common phenolcarboxylic and tannic constituents (PTCs). Using this method, quantitative analysis was accomplished in CF and other four adulterants, […]

Pyrazinacenes are linearly fused heteroaromatic rings, with N atoms replacing all apical CH moieties. Component rings may exist in a reduced state, having NH groups instead of N, causing cross-conjugation. These compounds have interesting optical and electronic properties, including strong fluorescence in the near-infrared region and photocatalytic properties, leading to diverse possible applications in bio-imaging […]

Quercetin, a flavonoid polyphenol found in many plants, has garnered significant attention due to its potential cancer chemoprevention. Our previous studies have shown that acetyl modification of the hydroxyl group of quercetin altered its antitumor effects in HepG2 cells. However, the antitumor effect in other cancer cells with different gene mutants remains unknown. In this […]

In this article, we introduce a proof-of-concept strategy, Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM), to expedite the discovery of drug metabolites. The use of a bioactive natural product, piperine, that has a well-curated metabolite profile but an unpredictable computational metabolism (Biotransformer v3.0) was selected. We developed an electrochemical reaction to oxidize piperine into […]

(1) Background: The aim of the work is the evaluation of in vitro antiproliferative and pro-apoptotic activity of four benzimidazole derivatives containing colchicine-like and catechol-like moieties with methyl group substitution in the benzimidazole ring against highly invasive breast cancer cell line MDA-MB-231 and their related impairment of tubulin dynamics. (2) Methods: The antiproliferative activity was […]